ANTISERA TO GONADOTROPHINS AND PLACENTAL FUNCTION IN MICE

Circulating levels of gonadotrophins in immature mice treated neonatally with antisera to gonadotrophins.

An immunological cross reaction between monkey gonadotrophin preparations and antisera to human gonadotrophins.

There is still some confusion about the ability of monkey and human gonadotrophins to cross react in immunological systems. McGarry & Beck (1963), using a haemagglutination inhibition technique, found a cross reaction between antisera to human fsh and monkey fsh. They also found a similar cross reaction with lh. Neill, Peckham & Knobil (1967), Bagshawe, Orr & Godden (1968) and Faiman, Ryan, Gre...

Campylobacter rectus Infection Impairs Placental Function and Development in Mice

Cloning and production of antisera to human placental 11 beta-hydroxysteroid dehydrogenase type 2.

By inactivating potent glucocorticoid hormones (cortisol and corticosterone), 11 beta-hydroxysteroid dehydrogenase type 2 (11 beta-HSD2) plays an important role in the placenta by controlling fetal exposure to maternal glucocorticoids, and in aldosterone target tissues by controlling ligand access to co-localized glucocorticoid and mineralocorticoid receptors. Amino acid sequence from homogeneo...

Obesity and Placental Function.

An increasing number of women of reproductive age are obese which affects the continuum of pregnancy and is associated with an increased incidence of adverse maternal and fetal outcomes, including preeclampsia, preterm birth, stillbirth, congenital anomalies, and macrosomia. Maternal obesity is associated with an increased incidence of metabolic and cardiovascular disease later in life in the m...